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Dyskinesia is a side effect caused by prolonged use of which one of the following chemical agents for treatment of Parkinson's disease?

A. Acetylcholinesterase
B. L-dopa
C. Botulinum
D. Baclofen
E. Gamma-aminobutyric acid (GABA) agonists

  • #1
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ANS: B
Rationale: Prolonged use of L-dopa for treatment of Parkinson's disease can cause dyskinesia because the drug L-dopa is converted to dopamine is converted to dopamine in the brain and an excess of dopamine in the striatal output pathway disinhibits the motor thalamus. In turn the motor thalamus overstimulates the motor areas of the cerebral cortex, producing involuntary movements.

  • #2
My sincere thanks.