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Which of the following is (are) associated with the emergence of focal hand dystonia?

A. Excessive repetition or overuse
B. Somatotopic degradation of somatosensory cortex
C. Central impairment of proprioception
D. Both A and B
E. A, B, and C

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ANS: E
Rationale: Excessive repetition or overuse of the hand causes somatotopic degradation of somatosensory cortex and central impairment of proprioception, leading to focal hand dystonia in genetically susceptible people.

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