Of the following situations, which one would be an example of a maladaptive cellular change?
An 18-year-old body builder who has developed extremely large pectoral muscles following years of weight lifting
A 31-year-old marathon runner who has developed hypertrophied myocardial cells
A 54-year-old female who has developed ovarian atrophy following loss of estrogen stimulation during menopause
A 44-year-old male with a 60-pack-per year smoking history who was diagnosed with a histological grade 3 lung cancer